MIT Sloan finance professor Andrew Lo applies a hedge fund approach to increasing investment in drug development
Lo does not fault Big Pharma for this dilemma, noting that most large pharmaceutical companies are public companies entrusted with a fiduciary duty to generate returns for shareholders. Nor does he blame venture capitalists, as they are not in business to risk a $30 million investment in one company’s projects. It appeared that neither public nor private equity was the best vehicle to fund biomedical innovation.
The alternative is what Lo and his colleagues at MIT Sloan have devised, a $30 billion megafund to develop drugs treating cancer, and a smaller, less-than-$1 billion investment portfolio targeting orphan drugs. The large amount of the megafund is based on evidence that it requires at least $200 million in out-of-pocket costs to investigate and develop a single therapeutic compound, from beginning to end. For a high rate of success, the fund would need at least 150 of these shots.
The smaller portfolio for orphan diseases recognizes the significantly higher odds of a new orphan drug receiving FDA approval versus those aimed at curing cancer—22 percent versus 6 or 7 percent.
Both portfolio financing strategies are in the proposal stage, and Lo is confident of their eventual success. Until then, his campaign to apply financial tools to curing deadly illnesses continues. It’s worth a shot.
"Now the world must show its colours," Merkel told the fifth informal meeting in Berlin of representatives of 35 countries, which was held to discuss a new climate change treaty.
"Every delay comes at a high cost," she said.
The 750 million euros form part of Germany‘s contribution to build up the green climate fund, which has been set up to help developing nations address climate change. Germany has spent 3.2 billion euros in recent years on efforts to tackle climate change.
"In Germany we are accepting our responsibility," the chancellor told the meeting, which is known as the Petersberg Climate Dialogue and which was created to overcome differences in the international community so that a new accord can be signed by the end of 2015.
The United Nations-sponsored green climate fund hopes to raise up to 100 billion dollars a year by 2020 to help with the promotion of climate-friendly businesses and to boost renewable energy.
...Estimates suggest that 7.2 million students will be seeking tertiary education abroad by 2025...
1.2 Focus of this project This project reviews national government- funded outward mobility scholarship schemes in eleven countries (Brazil, China, Egypt, India, Indonesia, Kazakhstan, Mexico, Pakistan, Russia, Saudi Arabia and Vietnam) with the goal of better understanding why governments sponsor these programmes; how they are designed, administered, and funded; who participates and where they study; and what impact the programmes are having...
“I highly recommend this book to both the professional and leisure reader. Erin has shown to be one of the main representatives of the next generation scholars who combine deep conceptual models with very practical applications. A must-read!”—Fons Trompenaars, Author of Riding the Waves of Culture
Key Factors to Become a Global Startup, The Spanish Institute for Foreign Trade (ICEX) curates this panel on Internationalization. Four internationally successful Spanish entrepreneurs will be the participants. Some of them are living outside, and from there to grow their businesses in Spain. These entrepreneurs will explain the difficulties they found when setting up their businesses.
The Center for American Studies offers students the opportunity to explore the experience and values of the people of the United States as embodied in their history, literature, politics, art, and other enduring forms of cultural expression.
Andrew Delbanco for his insight into the American character, past and present. He has been called “America’s best social critic” for his essays on current issues and higher education. As a professor in American studies, he reveals how classics by Melville and Emerson have shaped our history and contemporary life.
It is also true, however, that such training does not provide an adequate foundation for addressing the more abstract, but profoundly important, questions that ultimately must guide global policy and decision-making. For example:
How can the imperative of economic development be reconciled with the need to limit climate change?
What does national sovereignty mean in a world where diseases, pollutants, and terrorists cross national borders at will?
Are there universal human rights that transcend conflicting claims of particular cultural traditions?
How should limited resources be distributed in order to provide opportunity and hope to young people, while treating the elderly with dignity and respect?
What are a country’s obligations to refugees fleeing from persecution, poverty, or strife elsewhere?
How should we balance individual liberty and collective security?
In answering such questions, advances in science and technology (for example, new methods of energy production, surveillance, or online learning) will have a key role to play. But moral and ethical questions never yield fully to technical solutions; they also require an understanding of humanity’s social and cultural heritage. Science can help us to attain the life we want, but it cannot teach us what kind of life is worth wanting...
31 Aug 2012.
Columbia Business School professors Joseph Stiglitz and Bruce Greenwald discuss co-teaching the EMBA course Globalization, Markets, and the Changing Economic Landscape, while students share their experiences studying with such accomplished — and politically divergent — economic luminaries.
Open Doors, supported by a grant from the Bureau of Educational and Cultural Affairs at the U.S. Department of State, is a comprehensive information resource on international students and scholars studying or teaching at higher education institutions in the United States, and U.S. students studying abroad for academic credit at their home colleges or universities.
Data from the 2012 Open Doors Report was released on November 12.
A growing population, increasing shortages of resources, and national economies that are heavily in debt – the world is facing enormous challenges over the coming decades. Business is going to play a key role in solving these problems. “Never before, have companies and society been so closely connected,” says Pierre Tapie, President of the ESSEC Business School.
Together with Keio Business School in Tokyo, the School of Management of Fudan University in Shanghai, ESSEC Business School in France and the Business School of the University of Mannheim, Tuck forged an alliance of leading business schools from all parts of the world. (CouncilOnBusinessAndSociety.com) The alliance has a clear goal: to debate central economic and societal questions of the future, and to develop problem-solving approaches, while embedding them in research and education. More than 200 high-profile professors, business representatives, and students from the home countries of the five alliance partners participated in the first Forum and the focus was on questions that are both current and controversial: How can we best shape corporate governance? How should business leaders deal with the increased scrutiny of corporate actions? And what solutions exist for the tension-laden issue of balancing profitability with responsibility to multiple stakeholders?
These are topics that will have an impact on the education of future managers as well. A study conducted amongst graduate students at the five cooperating business schools shows that future leaders in the United States already regard ethical conduct as one of the most important qualities of a successful top manager. Internationally, this attribute ranks second to competence in financial questions, but ahead of both strategic orientation and the ability to motivate employees...
With the rise of China as an economy, a question hangs in
the air: Can America beat state capitalism? The evidence is not
encouraging. The U.S. has lost millions of jobs to the Chinese. It will
lose millions more if China, as it proposes, turns itself into a
high-tech giant in critical industries ranging from telecommunications
The rise of state capitalism has put the U.S. at a
competitive disadvantage. State capitalism operates with zero-sum rules,
in which one country gains as another loses. This is hardball
competition, dog eat dog. And the Chinese dog is eating the American one
in products ranging from cell phones to steel.
capitalism is not the form of capitalism U.S. policymakers see as the
challenge in global markets. U.S. policymakers are guided instead by the
idea of a win-win world. When everyone trades freely, business expands
across the board. Every country wins. This free-market, open-trade
approach is enshrined in the World Trade Organization...
Sir, In the catalogue of bad ideas (of which there have been many recently), surely that of a European Union-Japan free trade agreement deserves a gold medal for sheer imbecility (“Brussels to push Japan for trade deal”, July 18)...
In the process, the multilateral trade regime has been dramatically eroded and the WTO negotiations have become an expensive farce – expensive in terms of time, money, environmental footprint (all those needless high-level trade meetings), carbon dioxide emissions (all the hot air generated) and in the costs to global trade governance...
Over the past three decades, a global labor market has taken shape, spurring a massive movement from “farm to factory” in emerging markets and boosting output and productivity. But today, the strains on this labor force are becoming painfully evident.
In an accompanying video interview, former deputy governor of the Reserve Bank of India Rakesh Mohan highlights some of the challenges facing policy makers and business leaders.d supply imbalances for tens of millions of skilled and unskilled workers alike. In an accompanying video interview, former deputy governor of the Reserve Bank of India Rakesh Mohan highlights some of the challenges facing policy makers and business leaders....
Based on current trends in population, education, and labor demand, the report projects that by 2020 the global economy could face the following hurdles:
38 million to 40 million fewer workers with tertiary education (college or postgraduate degrees) than employers will need, or 13 percent of the demand for such workers
The world is bumpy: globalization and new strategies for growth draws on three sources of original research: The 2011 Globalization Survey, an online survey of 992 global business executives conducted for Ernst & Young by the Economist Intelligence Unit; in-depth interviews with senior executives and high-level experts conducted at end- 2011; and data from Ernst & Young’s Globalization Index 2011, which measures the 60 largest countries by GDP according to their degree of globalization.
Jagdish Bhagwati is a Chazen Advisor, Professor of Economics and Law at Columbia University, and Senior Fellow in International Economics at the Council on Foreign Relations. He recently edited, with Gordon Hanson, Skilled Migration Today.
While developed countries are angst-ridden over mostly illegal immigration by unskilled workers from developing countries, a different set of concerns has surfaced in Africa, in particular, over the legal outflow of highly skilled people to developed countries. This outflow is supposedly a new and damaging “brain drain,” with rich countries actively luring away needed skills from poor countries.
This fear is misplaced...
First, stop crying over the fact that the diaspora is not returning home. Instead, nurture the loyalty of professionals settling abroad, so that they assist their home countries in a variety of ways...
...when development has taken off, and conditions have improved sufficiently to attract people back to their homelands, the hugely increased diaspora would indeed return, as they have done in India, South Korea, and China.
As some of our readers are from Spain (1. USA, 2. UK, 3. India, 4. Spain, 5. Canada, 6. Netherlands, 7. France, 8. South Korea, 9. Germany...) we thought we would start the year with a Spanish video series on exporting, shown on Spanish TV with ICEX, the Spanish Insitute of Foreign Trade.
Short of a very rapid change in investor behavior and adoption of new policies in the largest emerging economies, the role of equities in the global financial system may be reduced in the coming decade.more